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Lisa M Savage Selected Research

Pyrithiamine

1/2021Sex differences in cholinergic circuits and behavioral disruptions following chronic ethanol exposure with and without thiamine deficiency.
12/2020The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum.
4/2016Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior.
7/2012Thiamine deficiency degrades the link between spatial behavior and hippocampal synapsin I and phosphorylated synapsin I protein levels.
6/2012Translational rodent models of Korsakoff syndrome reveal the critical neuroanatomical substrates of memory dysfunction and recovery.
4/2012Sustaining high acetylcholine levels in the frontal cortex, but not retrosplenial cortex, recovers spatial memory performance in a rodent model of diencephalic amnesia.
5/2011Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome.
11/2010Memory for reward location is enhanced even though acetylcholine efflux within the amygdala is impaired in rats with damage to the diencephalon produced by thiamine deficiency.
9/2010Cortical cholinergic abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat.
3/2010Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia.
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Lisa M Savage Research Topics

Disease

20Thiamine Deficiency
01/2021 - 07/2003
11Amnesia (Dissociative Amnesia)
04/2012 - 07/2003
4Korsakoff Syndrome (Wernicke-Korsakoff Syndrome)
04/2016 - 01/2004
3Cognitive Dysfunction
01/2021 - 11/2015
2Neuroinflammatory Diseases
01/2019 - 01/2019
1Binge Drinking
01/2021
1Nervous System Diseases (Neurological Disorders)
01/2018
1Memory Disorders (Memory Loss)
07/2012
1Dementia (Dementias)
11/2011
1Dyskinesias (Dyskinesia)
06/2011

Drug/Important Bio-Agent (IBA)

17PyrithiamineIBA
01/2021 - 07/2003
9Cholinergic Agents (Cholinergics)IBA
01/2021 - 03/2007
7Ethanol (Ethyl Alcohol)IBA
01/2021 - 11/2011
6Acetylcholine (Acetylcholine Chloride)FDA Link
04/2012 - 01/2007
3Proteins (Proteins, Gene)FDA Link
01/2019 - 11/2011
1Drinking WaterIBA
12/2020
1Thiamine (Aneurin)FDA Link
12/2020
1IsofluraneFDA LinkGeneric
01/2019
1General AnestheticsIBA
01/2019
1Nerve Growth Factor (NGF)IBA
01/2018
1Synapsins (Synapsin I)IBA
07/2012
1Neurotransmitter Agents (Neurotransmitter)IBA
11/2011
1Nerve Growth Factors (Neurotrophins)IBA
11/2011
1salicylhydroxamic acid (SHAM)IBA
06/2011
1Dopamine (Intropin)FDA LinkGeneric
06/2011
1Glutamic Acid (Glutamate)FDA Link
06/2011
15-HT1A Serotonin ReceptorIBA
06/2011
1SK&F 81297IBA
06/2011
1Levodopa (L Dopa)FDA LinkGeneric
06/2011
1Cholinesterase Inhibitors (Anticholinesterases)IBA
03/2010
1Tacrine (Cognex)FDA Link
03/2010
1GABA-A Receptors (GABA(A) Receptor)IBA
05/2009

Therapy/Procedure

1Injections
12/2020